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A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss. endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer, skin diseases and type II diabetes
Scopus
Toplam 222 atıf DOI
The interest of medicinal plants as therapeutic agents against diseases such as Alzheimer, skin disorders and diabetes mellitus is growing. In order to investigate the influence of Haplophyllum myrtifolium, four solvent extracts (petroleum ether, ethyl acetate, methanol and water) were screened for antioxidant potentials, anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glycosidase activity. Antioxidant effects were elucidated by different assays including free radical scavenging (ABTS, DPPH and NO assay), reducing power (FRAP and CUPRAC), phosphomolybdenum, β-carotene/linoleic acid system and metal chelating. Total phenolic, flavonoid, flavanol, tannin and saponin contents in these extracts were also calculated. Generally, ethyl acetate extract showed the strongest antioxidant activity in these extracts. This activity may be related to a good total phenolic content. The total phenolic contents of these extracts ranged from 32.32 to 52.50. mg GAEs/g extract. Except for water extract, all extracts showed good inhibitory activities on cholinesterase, tyrosinase, amylase and glycosidase. Apolar extracts (petroleum ether and ethyl acetate) were more potent as enzyme inhibitors in comparison to polar extracts (methanol and water). These findings reveal that H. myrtifolium could be used a source of natural compounds for the management of oxidative damage, Alzheimer, skin disorders and diabetes mellitus. © 2014 Elsevier B.V.
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Phytochemical Profiling, Antioxidant Capacity, Enzyme Inhibitory Potential, and Molecular Docking Insights of Brassica elongata Ehrh.
Scopus
Havuzumuzda
This study aimed to evaluate the phytochemical composition and bioactive potential, including antioxidant and enzyme inhibitory activities, of methanol extracts from different tissues of Brassica elongata. The most dominant phenolic compound, determined in all tissues by LC-MS/MS, was hyperoside, with the highest value of 897.7 µg/g in leaf tissue. The leaf extract exhibited the highest total phenolic content (TPC) and total flavonoid content (TFC), as well as total antioxidant, copper-reducing, and metal-chelating capacities among the tested tissues. In contrast, the flower extract showed the greatest ferric-reducing antioxidant potential and relatively strong radical-scavenging activity. Among the tested extracts, acetylcholinesterase (AChE) inhibition was observed only in the flower and fruit extracts, while all tissues showed comparable butyrylcholinesterase (BChE) inhibition activities. The flower extract exhibited the highest tyrosinase inhibitory potential, whereas the fruit extract showed the strongest α-amylase and relatively lower α-glucosidase inhibition, indicating distinct enzyme-specific activities among tissues. Docking results highlight the superior multi-target inhibitory potential of ellagic acid and hyperoside, suggesting their relevance in oxidative stress–related disorders. As demonstrated by this study, the antioxidant and enzyme inhibitory properties of B. elongata extracts underscore the plant's pharmacological relevance and its potential for developing functional ingredients.
Atıf Yapan Makale Bilgileri
Kurumlar (2)
Afyon Kocatepe Üniversitesi
Afyonkarahisar, Turkey
Selçuk Üniversitesi
Selçuklu, Turkey