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Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L. species
Scopus
Toplam 223 atıf DOI
The methanol and aqueous extracts of three endemic Centaurea species (C. polypodiifolia var pseudobehen, C. pyrrhoblephara and C. antalyense) were investigated for their antioxidant and cholinesterase inhibitory activities. The antioxidant activities of these extracts were evaluated by in vitro models including, phosphomolybdenum assay, free radical scavenging assays (DPPH and ABTS), β-carotene/linoleic acid test system, metal chelating assay, FRAP assay, ferric and cupric reducing power. Cholinesterase inhibitory activities were examined using Ellman's colorimetric method. Total phenol, flavonoid, and saponin contents were also measured. Among the six Centaurea extracts evaluated, the highest antioxidant abilities were obtained from C. polypodiifolia var pseudobehen. Methanolic extracts from C. polypodiifolia var pseudobehen and C. antalyense had a noticeable inhibition towards AChE and BChE. These findings suggest that Centaurea species could be an anticholinesterase agent and antioxidant resource in some industries, such as food, pharmacology, and cosmetics. © 2013 Elsevier Ltd.
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An endemic plant in turkey: antioxidant and enzyme ınhibition potential of different extracts of Asyneuma linifolium subsp. eximium
Scopus
Havuzumuzda
Plants have long been employed in traditional medicine as accessible and safer alternatives to synthetic drugs. Despite advances in pharmacology, herbal remedies remain important sources of bioactive compounds. This study investigated the biological properties of Asyneuma linifolium subsp. eximium, a species with limited prior research. The total phenolic and flavonoid contents and antioxidant activities were determined through DPPH, ABTS, FRAP, CUPRAC, PBD, and MCA assays. The methanol extract exhibited the highest ABTS activity (102.43 ± 0.97 mg TEs/g), while the ethyl acetate extract showed the strongest CUPRAC activity (45.59 ± 0.20 mg TEs/g). HPLC analysis identified epicatechin (14.66 ppm) as the predominant phenolic compound. Enzyme inhibition assays revealed notable activities against α-amylase (365.24 and 220.97 ACEs/g for ethyl acetate and methanol extracts, respectively) and α-glucosidase (444 ± 2.1 and 542 ± 2.1 ACEs/g, respectively), indicating potential relevance to type 2 diabetes management. Overall, these findings highlight A. linifolium subsp. eximium as a promising source of natural antioxidant and enzyme inhibitory agents with pharmacological potential.
Atıf Yapan Makale Bilgileri
Kurumlar (2)
Aksaray Üniversitesi
Aksaray, Turkey
Selçuk Üniversitesi
Selçuklu, Turkey