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Cytotoxic and enzyme inhibitory potential of two potentilla species (P. speciosa L. and P. reptans Willd.) and their chemical composition
Scopus
Open Access Toplam 345 atıf DOI
In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive components, and individual phenolic components were determined using photometric and HPLC methods, respectively. The main identified phenolic compounds in these extracts were rutin and catechin. Methanol and water extracts contained the highest total phenolic and flavonoid content. The results of antioxidant assays showed that methanol and water extracts displayed higher antioxidant activity compared to the ethyl acetate extract. Generally, methanol and water extracts exhibited higher biological activities correlated with higher levels the bioactive components. For P. speciosa, the methanol extract exhibited the highest enzyme inhibitory activity (except BChE inhibitory activity). P. reptans exhibited also high antiproliferative activity against MCF-7 cells whilst P. speciosa had weak to moderate activity against both of A549 and MCF-7 cell lines. The results suggest that Potentilla species could be potential candidates for developing new phyto-pharmaceuticals and functional ingredients.
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From plant to potential therapy: antioxidant and anticancer potential of Medicago lupulina and Trifolium arvense
Scopus
Havuzumuzda 1 atıf almış
BACKGROUND: Natural products with strong antioxidant properties and selective cytotoxic effects are increasingly recognized as promising candidates for cancer-related applications. In this context, Medicago lupulina and Trifolium arvense have garnered interest due to their diverse phytochemical profiles. This study aimed to compare the antioxidant potential and cytotoxic activity of methanolic and ethyl acetate extracts obtained from the aerial parts of both species. RESULTS: The methanolic extract of T. arvense exhibited the highest total phenolic and flavonoid contents, with values of 47.46 mg GAEs g−1 and 42.28 mg REs g−1, respectively. It demonstrated excellent antioxidant activity, with strong radical scavenging capacities (DPPH and ABTS values of 47.37 mg TEs g−1 and 95.18 mg TEs g−1). Meanwhile, M. lupulina extracts, especially the ethyl acetate one, showed significant metal chelating activity at 17.89 mg EDTAs g−1. In cytotoxicity tests, T. arvense's methanolic extract had a strong antiproliferative effect on HeLa cancer cells, with half-maximal inhibitory concentration (IC50) values of 0.492, 0.954, and 0.515 mg mL−1 at 24, 48, and 72 h, respectively, and lower toxicity towards L929 fibroblast cells. All results were statistically significant (P < 0.05). CONCLUSION: The methanolic extract of T. arvense has been identified as a powerful source of natural antioxidants that exhibit selective anticancer properties. This highlights its potential importance for future pharmaceutical and nutraceutical applications. These findings establish a strong scientific foundation for further in vivo and mechanistic studies. © 2026 Society of Chemical Industry.
Atıf Yapan Makale Bilgileri
Kurumlar (2)
Aksaray Üniversitesi
Aksaray, Turkey
Selçuk Üniversitesi
Selçuklu, Turkey