Kurumun Atıf Alan Makalesi
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Phytol: A review of biomedical activities
Scopus
Toplam 461 atıf DOI
Phytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applications in the pharmaceutical and biotechnological industry. There is ample evidence that PA may play a crucial role in the development of pathophysiological states. Focusing on PYT and some of its most relevant derivatives, here we present a systematic review of reported biological activities, along with their underlying mechanism of action. Recent investigations with PYT demonstrated anxiolytic, metabolism-modulating, cytotoxic, antioxidant, autophagy- and apoptosis-inducing, antinociceptive, anti-inflammatory, immune-modulating, and antimicrobial effects. PPARs- and NF-κB-mediated activities are also discussed as mechanisms responsible for some of the bioactivities of PYT. The overall goal of this review is to discuss recent findings pertaining to PYT biological activities and its possible applications.
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Atıf Yapan Yayın
Essential oil of Cleome coluteoides (Boiss.): phytochemical constituents, antioxidant, antimicrobial, antiproliferative, anti-inflammatory, enzymatic inhibition, and xanthine oxidase inhibitory properties
Scopus
Havuzumuzda 17 atıf almış
Introduction: Plant based natural products are well known for their therapeutic potential as they are used to treat many diseases, but these plants need to be validated through the scientific study. Therefore, the present investigation was carried out to evaluate the usefulness of the bioactive compounds present in the essential oils of the Cleome coluteoides. Methods: Different parts of the plant, including leaves, flowers, fruits, stems and roots, were used to extract the essential oils. The chemical composition of essential oils was analysed by gas-chromatography mass spectrometry (GC-MS). Their antimicrobial properties were evaluated against several human pathogens (three fungi and four bacteria). The enzyme inhibition activity (α-amylase, tyrosinase, butyrylcholinesterase, acetylcholinesterase inhibitory tests) of the essential oils was evaluated, along with, their antioxidant activity (DPPH, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) tests), xanthine oxidase inhibitory activity, antiproliferative activity (against MCF-7 and Hep-G2), anti-arthritic activity (protein denature assay), and anti-inflammatory activity. Results: Phytol, sclareol, 7-α-hydroxy manool, and piperitone were found to be the main compounds of the studied essential oils. Notable antibacterial, antifungal, enzyme inhibition, antioxidant, xanthine oxidase inhibitory, antiproliferative, anti-arthritic, and inflammatory activities were found form the essential oils. The best activity was found in the case of the essential oils made from leaves. Discussion/Conclusions: These potential biological activities along with the chemical constitutes present in the essential oils of C. coluteoides can make them potentially utilisable in different biomedical and therapeutic applications in the future. Additionally, the studied plant and their essential oils can serve as a natural remedy for a variety of lifestyle diseases.
Atıf Yapan Makale Bilgileri
Kurumlar (7)
Chettinad Academy of Research and Education
Kelambakkam, India
Maharaja Sriram Chandra Bhanja Deo University
Baripada, India
Politechnika Wrocławska
Wroclaw, Poland
Selçuk Üniversitesi
Selçuklu, Turkey
University of Oxford
Oxford, United Kingdom
University of Science and Technology Meghalaya
Baridua 9th Mile, India
University of Zabol
Zabol, Iran