The relationship between glutathione peroxidase and bioimpedance parameters in nondiabetic hemodialysis patients

There is growing evidence from experimental and clinical studies that oxidative stress is involved in the pathogenesis of malnutrition. This cross-sectional study aimed to investigate the relationship between glutathione peroxidase (GPx) levels as a marker of antioxidant status and the nutritional status assessed by bioimpedance analysis (BIA). Ninety-seven nondiabetic stable outpatient uremic adults undergoing chronic hemodialysis (HD) were recruited for this study. Impedance measurements were performed using a multifrequency bioelectrical impedance analyzer after dialysis. GPx levels correlated with intracellular water (ICW) (r=0.341, P=0.011), ICW/total body weight (r=0.320, P=0.017), lean body mass (r=0.300, P=0.026) and total body cell mass (r=0.339, P=0.011). When patients were divided into two groups according to mean GPx levels (83.9 U/gr hemoglobin), the patients with higher GPx (GPx>83.9U/gr hemoglobin) had higher albumin (P=0.038), lean body mass (P=0.026), ICW (P=0.011), and total body cell mass (P=0.011) compared with those with lower GPx (GPx≤83.9 U/gr hemoglobin). Furthermore, in the patients with higher GPx, body fat; extracellular water/total body water; illness marker and body fat mass index were lower than other group. In conclusion, our results reveal correlation indicating a relationship between antioxidant status (as measured by GPx) and nutritional status as assessed by BIA in nondiabetic HD patients. © 2011 The Authors. Hemodialysis International © 2011 International Society for Hemodialysis.