Markers that are used for allergic diseases can the be used in preeclampsia?

Objective: We aimed to investigate the relationship between inflammatory markers used for allergic diseases and preeclampsia. Material and Methods: This retrospective case-control study included 162 patients comprising 81 patients in the control group and 81 patients in the preeclampsia group. The preeclampsia group was constituted by 40 patients with mild preeclampsia and 41 with severe preeclampsia. The basophil, eosinophil, eosinophil-basophil ratio (EBR), eosinophil-lymphocyte ratio (ELR), and basophil-lymphocyte ratio (BLR) values used in this study were taken into account before the initiation of any medical or surgical procedure. Results: EBR was significantly lower in the preeclampsia group than in the control group (p=0.033). Basophil (p=0.049) and BLR (p=0.029) values were significantly higher in the preeclampsia group than in the control group. When the control group and preeclampsia subgroups were compared, ELR and EBR were significantly different between three groups ((p=0.039 and p=0.010 respectively) but in binary comparison no difference was found. As preeclampsia severity increased, EBR decreased, and ELR increased gradually. To predict preeclampsia, the receiver operating characteristic curve (ROC) analysis was used. The ROC analysis results of EBR was found as sensitivity 51.90%, and specificity 69.1% (AUC:0.597, 95% CI:0.51-0.68), and BLR was found as sensitivity 62.85%, and specificity 59.78% (AUC:0.600, 95% CI:0.51-0.69). Conclusion: Allergy-related mechanisms may also play a role in the pathogenesis of preeclampsia. Allergic markers may be considered in the diagnosis and research of preeclampsia.