Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Science · Ekim 2020
Özet
Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally defined LOF variants underlying autosomal-recessive or autosomal-dominant deficiencies in 23 patients (3.5%) 17 to 77 years of age. We show that human fibroblasts with mutations affecting this circuit are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.
YÖKSİS Kayıtları
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Science · 2020 SCI-Expanded
Prof. Dr. MELİKE EMİROĞLU →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
SCIENCE · 2020 SCI
Doç. Dr. GÜLSÜM ALKAN →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
SCIENCE · 2020 SCI
Prof. Dr. FİKRET KANAT →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
American Association for the Advancement of Science (AAAS) · 2020 SCI-Expanded
Doç. Dr. GÜLSÜM ALKAN →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
SCIENCE · 2020 SCI
Prof. Dr. MELİKE EMİROĞLU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Bu dergide (ISSN eşleşmesi) kurumun 11 kaydı bulundu.
YÖKSİS Kayıtları — ISSN Eşleşmesi
Bu dergide (ISSN eşleşmesi) kurumun 11 kaydı bulundu.
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
2020 ISSN: 0036-8075 SCI
Prof. Dr. FİKRET KANAT →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
2020 ISSN: 0036-8075 SCI
Prof. Dr. FİKRET KANAT →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
2020 ISSN: 0036-8075 SCI-Expanded
Prof. Dr. MELİKE EMİROĞLU →
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
2023 ISSN: 0036-8075 SCI-Expanded Q1
Prof. Dr. MELİKE EMİROĞLU →
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
2023 ISSN: 0036-8075 SCI-Expanded Q1
Doç. Dr. GÜLSÜM ALKAN →
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
2020 ISSN: 0036-8075 SCI-Expanded Q1
Doç. Dr. GÜLSÜM ALKAN →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
2020 ISSN: 0036-8075 SCI-Expanded Q1
Prof. Dr. MELİKE EMİROĞLU →
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
2023 ISSN: 0036-8075 SCI-Expanded Q1
Prof. Dr. MELİKE EMİROĞLU →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
2020 ISSN: 0036-8075 SCI-Expanded Q1
Doç. Dr. GÜLSÜM ALKAN →
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
2023 ISSN: 0036-8075 SCI-Expanded Q1
Prof. Dr. JALE BENGİ ÇELİK →
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
2023 ISSN: 0036-8075 SCI-Expanded Q1
Prof. Dr. JALE BENGİ ÇELİK →
Makale Bilgileri
Dergi
Science
Toplam Atıf
1.805 atıf
· Scopus
ISSN00368075
Yayın TarihiEkim 2020
Cilt / Sayfa370
Scopus ID2-s2.0-85094120212
Erişim🔓 Açık Erişim
Kurumlar
Aix Marseille Université
Marseille France
Amsterdam UMC
Amsterdam Netherlands
AP-HM Assistance Publique - Hôpitaux de Marseille
Marseille France
Bilkent Üniversitesi
Ankara Turkey
Centre Hospitalier Universitaire Vaudois
Lausanne Switzerland
Chang Gung University
Taoyuan Taiwan
CH de Gonesse
Gonesse France
Children's Healthcare of Atlanta
Atlanta United States
College of Medicine
Riyadh Saudi Arabia
Columbia University
New York United States
Dasman Diabetes Institute
Dasman Kuwait
École Polytechnique Fédérale de Lausanne
Lausanne Switzerland
Garvan Institute of Medical Research
Sydney Australia
Helix OpCo LLC
San Diego United States
Hopital Avicenne
Bobigny France
Hôpital Bichat-Claude-Bernard AP-HP
Paris France
Hôpital Erasme
Brussels Belgium
Hôpital Necker Enfants Malades
Paris France
Hôpital Tenon
Paris France
Hôpital Universitaire Pitié Salpêtrière
Paris France
Hospital de Gran Canaria Dr. Negrin
Las Palmas de Gran Canaria Spain
Hospital Duran i Reynals
Barcelona Spain
Hospital General Universitario de Valencia
Valencia Spain
Hospital Universitari Vall d'Hebron
Barcelona Spain
Icahn School of Medicine at Mount Sinai
New York United States
Imperial College London
London United Kingdom
Inserm
Paris France
Institut de Recherche Saint-Louis
Paris France
Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS
Barcelona Spain
Institute for Systems Biology
Seattle United States
Institut Pasteur, Paris
Paris France
Institut Pierre Louis d'Epidémiologie et de Santé Publique
Paris France
Karolinska Institutet
Stockholm Sweden
King Abdulaziz City for Science and Technology
Riyadh Saudi Arabia
King Abdulaziz Medical City - Riyadh
Riyadh Saudi Arabia
King Saud bin Abdulaziz University for Health Sciences
Riyadh Saudi Arabia
King Saud University
Riyadh Saudi Arabia
Konya Meram Training and Research Hospital
Konya Turkey
KU Leuven
Leuven Belgium
KU Leuven– University Hospital Leuven
Leuven Belgium
Leidos Inc.
Reston United States
L'Institut de Recherche du Centre Universitaire de Santé McGill
Montreal Canada
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda United States
National Research Institute of Tuberculosis and Lung Disease Tehran
Tehran Iran
Necmettin Erbakan Üniversitesi
Meram Turkey
Rockefeller University
New York United States
Shahid Beheshti University of Medical Sciences
Tehran Iran
SIB Swiss Institute of Bioinformatics
Lausanne Switzerland
Sidra Medicine
Doha Qatar
Sina Medical Complex
Ahvaz Iran
Spedali Civili Di Brescia
Brescia Italy
Tehran University of Medical Sciences
Tehran Iran
Uniformed Services University of the Health Sciences
Bethesda United States
Universidad de Antioquia
Medellin Colombia
Universidad Fernando Pessoa Canarias
Santa Maria de Guia de Gran Canaria Spain
Università degli Studi di Brescia
Brescia Italy
Università degli Studi di Milano-Bicocca
Milan Italy
Università degli Studi di Roma "Tor Vergata"
Rome Italy
Universitair Ziekenhuis Gent
Ghent Belgium
Université Paris Cité
Paris France
University of Health Sciences
Istanbul Turkey
Vall d'Hebron Institut de Recerca
Barcelona Spain
Vrije Universiteit Amsterdam
Amsterdam Netherlands
Washington University School of Medicine in St. Louis
St. Louis United States
Yale School of Medicine
New Haven United States
Son Atıflar
Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON)
Human Genomics
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Nature Communications
· 2026 · DOI
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Scimago Dergi (ISSN Eşleşmesi)
Science
Q1
OA
SJR Skoru10,948
H-Index1433
YayıncıAmerican Association for the Advancement of Science
ÜlkeUnited States
History and Philosophy of Science (Q1)
Multidisciplinary (Q1)
Metrikler
1805
Atıf