Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Science · Ekim 2020
Özet
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
YÖKSİS Kayıtları
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Science · 2020 SCI-Expanded
Doç. Dr. GÜLSÜM ALKAN →
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Science · 2020 SCI-Expanded
Prof. Dr. MELİKE EMİROĞLU →
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
SCIENCE · 2020 SCI
Prof. Dr. FİKRET KANAT →
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Science · 2020 SCI-Expanded
Prof. Dr. FİKRET KANAT →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Bu dergide (ISSN eşleşmesi) kurumun 11 kaydı bulundu.
YÖKSİS Kayıtları — ISSN Eşleşmesi
Bu dergide (ISSN eşleşmesi) kurumun 11 kaydı bulundu.
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
2020 ISSN: 0036-8075 SCI
Prof. Dr. FİKRET KANAT →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
2020 ISSN: 0036-8075 SCI
Prof. Dr. FİKRET KANAT →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
2020 ISSN: 0036-8075 SCI-Expanded
Prof. Dr. MELİKE EMİROĞLU →
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
2023 ISSN: 0036-8075 SCI-Expanded Q1
Prof. Dr. MELİKE EMİROĞLU →
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
2023 ISSN: 0036-8075 SCI-Expanded Q1
Doç. Dr. GÜLSÜM ALKAN →
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
2020 ISSN: 0036-8075 SCI-Expanded Q1
Doç. Dr. GÜLSÜM ALKAN →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
2020 ISSN: 0036-8075 SCI-Expanded Q1
Prof. Dr. MELİKE EMİROĞLU →
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
2023 ISSN: 0036-8075 SCI-Expanded Q1
Prof. Dr. MELİKE EMİROĞLU →
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
2020 ISSN: 0036-8075 SCI-Expanded Q1
Doç. Dr. GÜLSÜM ALKAN →
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
2023 ISSN: 0036-8075 SCI-Expanded Q1
Prof. Dr. JALE BENGİ ÇELİK →
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
2023 ISSN: 0036-8075 SCI-Expanded Q1
Prof. Dr. JALE BENGİ ÇELİK →
Makale Bilgileri
Dergi
Science
Toplam Atıf
2.237 atıf
· Scopus
ISSN00368075
Yayın TarihiEkim 2020
Cilt / Sayfa370
Scopus ID2-s2.0-85094096675
Erişim🔓 Açık Erişim
Kurumlar
Aarhus Universitet
Aarhus Denmark
Aarhus Universitetshospital
Aarhus Denmark
AP-HP Assistance Publique - Hopitaux de Paris
Paris France
Centre Hospitalier Lyon-Sud
Lyon France
Centre Universitaire de Santé McGill
Montreal Canada
CHU de Lyon
Lyon France
CNRS Centre National de la Recherche Scientifique
Paris France
Collège de France
Paris France
École Normale Supérieure de Lyon
Lyon France
Fondazione IRCCS Policlinico San Matteo
Pavia Italy
Fundació Institut dInvestigació en Ciències de la Salut Germans Trias i Pujol
Badalona Spain
Garvan Institute of Medical Research
Sydney Australia
Haukeland Universitetssjukehus
Bergen Norway
Helix OpCo LLC
San Diego United States
Hôpital Bichat-Claude-Bernard AP-HP
Paris France
Hopital Foch
Suresnes France
Hôpital Necker Enfants Malades
Paris France
Hôpital Universitaire Pitié Salpêtrière
Paris France
Hospital de Gran Canaria Dr. Negrin
Las Palmas de Gran Canaria Spain
Howard Hughes Medical Institute
Chevy Chase United States
Innovations Thérapeutiques en Hémostase
Paris France
Inserm
Paris France
Institució Catalana de Recerca i Estudis Avançats
Barcelona Spain
Institute of Genetics and Biophysics Adriano Buzzati Traverso
Naples Italy
Institut Pasteur, Paris
Paris France
Karolinska Institutet
Stockholm Sweden
Karolinska Universitetssjukhuset
Stockholm Sweden
L'Institut de Recherche du Centre Universitaire de Santé McGill
Montreal Canada
Mutua de Terrassa
Terrassa Spain
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda United States
National Institute of Dental and Craniofacial Research (NIDCR)
Bethesda United States
National Institutes of Health (NIH)
Bethesda United States
National Referee Centre for Rheumatic and AutoImmune and Systemic diseases in childrEn (RAISE)
Lyon France
Rockefeller University
New York United States
Sorbonne Université
Paris France
Spedali Civili Di Brescia
Brescia Italy
Tartu Ülikool
Tartu Estonia
Tartu Ülikooli Kliinikum
Tartu Estonia
Universidad de Antioquia
Medellin Colombia
Universidad Fernando Pessoa Canarias
Santa Maria de Guia de Gran Canaria Spain
Università degli Studi di Brescia
Brescia Italy
Università degli Studi di Milano-Bicocca
Milan Italy
Università degli Studi di Pavia
Pavia Italy
Universitair Ziekenhuis Gent
Ghent Belgium
Universitat de Vic - Universitat Central de Catalunya (UVic-UCC)
Vic Spain
Università Vita-Salute San Raffaele
Milan Italy
Universiteit van Amsterdam
Amsterdam Netherlands
Université Paris Cité
Paris France
Universitetet i Bergen
Bergen Norway
Uniwersytet im. Adama Mickiewicza w Poznaniu
Poznan Poland
UNSW Medicine
Kensington Australia
Yale School of Medicine
New Haven United States
Son Atıflar
Proteome-wide autoantibody screening and holistic autoantigenomic analysis unveil COVID-19 signature of autoantibody landscape
BMC Immunology
· 2026 · DOI
Single-cell transcriptomic analysis deciphers heterogeneity and transcriptional regulatory programs of sepsis with different prognosis
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Clinical Epigenetics
· 2026 · DOI
Autoantibodies to IL-1Ra and PGRN in severe COVID-19 are associated with inflammation-induced hyperphosphorylated antigen isoforms
Nature Communications
· 2026 · DOI
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID
Communications Medicine
· 2026 · DOI
SARS-CoV-2-induced IgG repertoires shape T cell responses, microRNA regulation, and autoreactivity according to disease severity
Journal of Translational Autoimmunity
· 2026 · DOI
Systemic multi-omics analysis reveals interferon response heterogeneity and links lipid metabolism to immune alterations in severe COVID-19
Genome Medicine
· 2026 · DOI
Global research landscape of inborn errors of immunity: a bibliometric analysis (1991–2025)
Orphanet Journal of Rare Diseases
· 2026 · DOI
Systematic Review and Meta-analysis of Anti-interferon Auto-antibodies in Infectious Diseases
Journal of Clinical Immunology
· 2026 · DOI
Good’s Syndrome Mirrors a Combined Immunodeficiency with Anti-Cytokine Antibodies in the Total Absence of B Cells
Journal of Clinical Immunology
· 2026 · DOI
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Scimago Dergi (ISSN Eşleşmesi)
Science
Q1
OA
SJR Skoru10,948
H-Index1433
YayıncıAmerican Association for the Advancement of Science
ÜlkeUnited States
History and Philosophy of Science (Q1)
Multidisciplinary (Q1)
Metrikler
2237
Atıf