Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
Science Immunology · Aralık 2023
Özet
Life-threatening "breakthrough"cases of critical COVID-19 are attributed to poor or waning antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting auto-Abs neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; their contribution to hypoxemic breakthrough cases in vaccinated people is unknown. We studied a cohort of 48 individuals (aged 20 to 86 years) who received two doses of a messenger RNA (mRNA) vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Ab levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal Ab response to the vaccine. Among them, 10 (24%) had auto-Abs neutralizing type I IFNs (aged 43 to 86 years). Eight of these 10 patients had auto-Abs neutralizing both IFN-a2 and IFN-w, whereas two neutralized IFN-w only. No patient neutralized IFN-b. Seven neutralized type I IFNs at 10 ng/ml and three at 100 pg/ml only. Seven patients neutralized SARS-CoV-2 D614G and Delta efficiently, whereas one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only type I IFNs at 100 pg/ml neutralized both D614G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating Abs capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a notable proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population.
YÖKSİS Kayıtları
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
American Association for the Advancement of Science (AAAS) · 2022 SCI-Expanded
Doç. Dr. DİLEK ERGÜN →
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
American Association for the Advancement of Science (AAAS) · 2022 SCI-Expanded
Prof. Dr. RECAİ ERGÜN →
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
American Association for the Advancement of Science (AAAS) · 2022 SCI-Expanded
Prof. Dr. FİKRET KANAT →
Makale Bilgileri
Dergi
Science Immunology
Toplam Atıf
70 atıf
· Scopus
Yayın TarihiAralık 2023
Cilt / Sayfa8
Scopus ID2-s2.0-85181178475
Erişim🔓 Açık Erişim
Kurumlar
Academy of Athens
Athens Greece
Agency for Science, Technology and Research, Singapore
Singapore City Singapore
AP-HP Assistance Publique - Hopitaux de Paris
Paris France
Bilkent Üniversitesi
Ankara Turkey
Centre Hospitalier Lyon-Sud
Lyon France
Centre International de Recherche en Infectiologie
Lyon France
Centre Universitaire de Santé McGill
Montreal Canada
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas
Madrid Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras
Madrid Spain
Centro Hospitalar Universitário de Santo António
Porto Portugal
Chan Zuckerberg Biohub
San Francisco United States
CHU de Lyon
Lyon France
CHU de Nantes
Nantes France
College of Medicine
Sharjah United Arab Emirates
College of Medicine
Riyadh Saudi Arabia
École Normale Supérieure de Lyon
Lyon France
Faculty of Medical Sciences, Goce Delcev University
Stip North Macedonia
Fondazione IRCCS Policlinico San Matteo
Pavia Italy
Fundació Institut dInvestigació en Ciències de la Salut Germans Trias i Pujol
Badalona Spain
Grand Hôpital de l’Est Francilien (Site de Marne-la-Vallée)
Jossigny France
Hôpital Bichat-Claude-Bernard AP-HP
Paris France
Hopital Edouard Herriot
Lyon France
Hopital Foch
Suresnes France
Hôpital Henri Mondor
Creteil France
Hopital Louis-Mourier
Colombes France
Hôpital Necker Enfants Malades
Paris France
Hopital Raymond Poincare
Garches France
Hôpital Saint-Louis
Paris France
Hôpital Universitaire Pitié Salpêtrière
Paris France
Hospital de Gran Canaria Dr. Negrin
Las Palmas de Gran Canaria Spain
Hospital Duran i Reynals
Barcelona Spain
Hospital Universitari de Bellvitge
Barcelona Spain
Hospital Universitario Infanta Leonor
Madrid Spain
Hôtel Dieu CHU de Nantes
Nantes France
I. Horbachevsky Ternopil National Medical University
Ternopil Ukraine
Infection, Anti-Microbien, Modélisation, Évolution
Paris France
Inserm
Paris France
Institució Catalana de Recerca i Estudis Avançats
Barcelona Spain
Institut d'Investigació Biomedica de Bellvitge
Hospitalet de Llobregat Spain
Institute of Public Health
Skopje North Macedonia
IRCCS Ospedale Pediatrico Bambino Gesù
Rome Italy
Karolinska Institutet
Stockholm Sweden
Lee Kong Chian School of Medicine
Singapore City Singapore
L'Institut de Recherche du Centre Universitaire de Santé McGill
Montreal Canada
Medizinische Universitat Innsbruck
Innsbruck Austria
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda United States
National Referee Centre for Rheumatic
Lyon France
Necmettin Erbakan Üniversitesi
Meram Turkey
Parker Institute for Cancer Immunotherapy
San Francisco United States
Physiopathologie de l'Immunodépression Associée aux Réponses Inflammatoires Systémiques
Lyon France
Rockefeller University
New York United States
Saint-Denis
Saint-Denis France
School of Biological Sciences
Singapore City Singapore
School of Medicine
Athens Greece
Shupyk National Healthcare University of Ukraine
Kyiv Ukraine
Sorbonne Université
Paris France
Spedali Civili Di Brescia
Brescia Italy
Sveučilište Josipa Jurja Strossmayera u Osijeku
Osijek Croatia
UCSF School of Medicine
San Francisco United States
Universidad Complutense de Madrid
Madrid Spain
Universidad de La Sabana
Chía Colombia
Universidad Fernando Pessoa Canarias
Santa Maria de Guia de Gran Canaria Spain
Università degli Studi di Roma "Tor Vergata"
Rome Italy
Universitat de Vic - Universitat Central de Catalunya (UVic-UCC)
Vic Spain
Université de Lyon
Lyon France
Université de Montpellier
Montpellier France
Université Paris Cité
Paris France
Université Paris-Est Créteil Val de Marne
Creteil France
University of California, San Francisco
San Francisco United States
University of Health Sciences
Istanbul Turkey
University of Ukraine
Kyiv Ukraine
University of Zagreb School of Medicine
Zagreb Croatia
Havuzumuzdaki Atıflar 0
Bu makaleye, sistemimizdeki Scopus veritabanında bulunan 0 makale atıf yapmıştır. Scopus genel atıf sayısı: 70.
Bu makaleye, kendi Scopus havuzumuzdaki başka bir makaleden atıf kaydı bulunmuyor.
Metrikler
70
Atıf