Animal Model of Human Cancer: Malignant Lymphoma/Colon Cancer/Lung Cancer/Liver Cancer/Brain Tumors/Skin Cancer

Considering that the number of people who died from cancer alone in 2020 is more than ten million, the importance of early diagnosis and treatment is once again important. New diagnostic methods and innovative treatments are being developed because the early detection and treatment rates of most types of cancer are insufficient. Selecting a suitable animal model for a given problem is occasionally random and usually a matter of convenience. As in preclinical disease models, selection of the appropriate animal model is very important, since no single animal model can mimic all clinical features in cancer studies. In particular, although mouse models whose genome shares 99% homology with the human genome take the traditional animal model for the molecular biology of cancer, other organisms such as rats, zebrafish, worms, cats, and dogs have been used as research models. Furthermore, although other species (such as dogs and pigs) are more closely related to humans than mice, they are not preferred due to ethical problems and the costs of these species. This chapter is aimed to discuss distinct animal models used in cancer studies and specific animal models for particular human cancer types.