The Effect of Grape Seed Extract on t he Pancreatic Weight in Diabetic Rats

Objective: The pancreas is a vital organ that produces metabolic hormones and enzymes. Type II diabetes either arises from defective insulin secretion from pancreatic beta-cell cells or a diminished pancreatic beta-cell mass. The possible effects of grape seed extract on various metabolic diseases have been investigated in recent years. This study was designed to determine the effect of grape seed extract therapy on pancreatic mass. Methods: Twenty-five rats were partitioned in five groups: Control, diabetes and treatment groups in which was administered 100, 200, and 400 mg/kg of the grape seed extract, respectively. Regarding the origin of diabetic rats, 35 mg/kg of STZ was injected intraperitoneally into the diabetic control and treatment groups. The grape seed extract was administered to the treatment groups via gavage per the indicated doses (100, 200, and 400 mg/kg extract) for 28 days. All rats were dispatched post treatment. After dispatching the rodents, their pancreatic masses were obtainedand noted. Data analysis was performed in order to determine the differences between groups using the Statistical Package for Social Sciences version 22-SPSS (IBM Statistics 22). Results: The pancreatic mass in diabetic rats was significantly (p<0.05) lower relative to the control rats. Equally, the pancreatic increased significantly in every treatment group compared to the control and diabetic groups (p<0.05). This increase was highest with the 400 mg/kg extract dose. Conclusion: Grape seed extracts might be effective reversing pancreatic insufficiency in STZ-diabetic rats.