Determination of ANAE and ACP-ase positive lymphocytes of peripheral blood and endometrium tissues in experimental hypothyroidism-induced rats

This study was aimed to provide information about the status of the immune system by revealing changes in peripheral blood leukocyte (PBL) percentages, ANAE-and ACP-ase(+) lymphocyte rates in peripheral blood (PB) and endometrium tissues of experimental hypothyroidism-induced rats. In this study, 15 healthy female Wistar Albino rats were used. Rats were fed through 4 weeks. The Group E (experimental, n=9) is group that were made hypothyroidism by intraperitoneal methimazole enjection for 2 weeks. Rats of the Group C (control, n=6) were untreated. In the 2 nd and 4 th weeks, ANAE-and ACP-ase(+) lymphocyte rates of the Group E were higher than Group C in PB. Excepting eosinophil and basophil leukocyte rates, there was no statistical difference in the other PBL percentages in the both of weeks. In PB, while lymphocyte rate of the 4 th week was no statistically different (P>0.05), it was found lower in Group C. There was no alteration in ANAE-and ACP-ase(+) lymphocyte rates of uterine tissue. As a result, whereas hypothyroidism caused significant alterations in PBL and T lymphocyte rates, the any marked changes was not observed in the uterine tissue.