The effects of aflatoxin and glucomannan on some antioxidants and biochemical parameters in rabbits

In this study the effects of aflatoxin added to the feed and the effects of glucomannan supplemented in order to prevent aflatoxin absorbtion on some biochemical parameters and antioxidants were studied in 40 New Zeland rabbits. The rabbits were randomly alloted to the following groups: control (C), glucomannan (G), glucomannan + aflatoxin (AG) and aflatoxin (A). At the end of the ten weeks trial MDA levels increased, GSH and SOD levels were decreased (p < 0.05) in group A compared with control group levels. Cholesterol, glucose, albumin and total protein levels also decreased, AST and ALT levels were increased in group A compared with the control group. In the group G the former parameters were not affected by glucomannan application alone. On the other hand in the AG group MDA, GSH, SOD, cholesterol, glucose, albumin and total protein levels were higher, while AST and ALT levels were lower compared with the control levels, although these differences were not significant. In conclusion, the results determined in the study might be important to demonstrate the effects of aflatoxicosis on some biochemical and antioxidant parameters.