The influence of Zinc adsorbed nano zeolite on some haematological and biochemical parameters and mineral levels in Cadmium toxicity

The aim of the study was to investigate the influence of zinc adsorbed nano – zeolite administration on some hematological and biochemical values as well as mineral levels in female Wistar rats exposed to cadmium. For this purpose, 32 female rats were selected and divided into four equal groups as control, cadmium, adsorbed nano – zeolite, and cadmium + adsorbed nano – zeolite. The rats in the cadmium and cadmium + adsorbed nano – zeolite groups received cadmium (2.04 mg·mL-1) orally by gastric gavage for 4 weeks. Besides, adsorbed nano – zeolite (8 g·kg-1 bw·day-1) was administered to adsorbed nano – zeolite and cadmium + adsorbed nano – zeolite groups for 4 weeks. At the end of the experiment, they were sacrificed and blood samples were taken to assess the erythrocytes, leukocytes, platelets, hemoglobin, hematocrit, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular volume, creatinine, blood urea nitrogen, creatinine/blood urea nitrogen, glucose, carbon dioxide, lactat, and pH values as well as calcium, phosporus, magnesium, sodium, chlorine, and potassium levels. As a result, cadmium administration reduced the erythrocytes counts in female Wistar rats (P<0.01). On the other hand, adsorbed nano – zeolite administration ameliorated the erythrocytes values in the cadmium + adsorbed nano – zeolite group when compared to the cadmium group (P<0.01). In addition, serum lactat and glucose levels were determined to be lowest in the adsorbed nano – zeolite group when compared to other experimental groups, interestingly (P<0.01). In this study, administration of cadmium and adsorbed nano – zeolite (alone or together) caused a significant decrease in serum magnesium levels of the experimental groups (P<0.001). In conclusion, adsorbed nano – zeolite administration caused remarkable changes in some blood and biochemical parameters of female Wistar rats exposed to cadmium.