Aim: This study aims to determine the effects of continuous nursing care applied with a preand postoperative coaching strategy to patients with total knee replacement on some patient outcomes (pain control, anxiety level, self-care power, activities of daily living, patient satisfaction, hospital readmission status, and use of painkillers). Materials and methods: This research was a parallel group (experiment-control) randomized controlled clinical trial. Data were obtained from patients who underwent 72 knee replacement surgeries between January 20, 2021, and October 28, 2021, using the Patient Identification Form, the Visual Analog Scale, the Self-Care Scale, the Newcastle Nursing Satisfaction Scale, the State Anxiety Inventory, and the Barthel Daily Living Activity Index. The patients were followed up preoperatively and postoperatively. This study is registered in the Clinical Trials database (NCT04683588). Results: Statistical analysis of the data obtained from this research was calculated using the SPSS 25 package program in the computer environment. Number, percentage, mean and standard deviation were used for descriptive statistics, and chi-square analysis was used to compare the similarity/homogeneity of the groups regarding descriptive characteristics. Obtained results were evaluated at a p<0.05 significance level. Conclusion: As a result of the research, it was concluded that the patients in the experimental group had a positive effect on pain, analgesic use, anxiety, self-care power, activities of daily living and patient satisfaction compared to the patients in the control group.