Aim: The aim of this study is to establish the correlation between the degree of psychological resilience and readiness for discharge in patients undergoing orthopaedic surgery. Design: This study is of a descriptive correlational type. Material and Method: This study comprised a cohort of 190 patients who were admitted to the orthopaedics and traumatology department and had surgical procedures performed between November 2023 and April 2024. The study data were gathered via completion of the Introductory Information Form, the Psychological Resilience Scale and the Hospital Discharge Readiness Scale. IBM SPSS 25 package program was used to analyse the research data. Results: In this study, 34.2% of the participants stated that they did not feel ready for discharge. Predictors of Readiness for Hospital Discharge were identified as being male (β = 0.118, p = 0.003), living alone (β = 0.222, p < 0.001), having undergone prosthesis, fracture or amputation surgery (β = 0.161, p < 0.001), not having received discharge training (β = 0.122, p = 0.001), not feeling ready for discharge (β = 0.442, p < 0.001) and resilience (β = 0.246, p < 0.001). These variables were found to explain 88.7% of Readiness for Hospital Discharge (adjusted R2 = 0.773). Conclusion: The findings of this study emphasise that including patients in their healthcare and creating comprehensive discharge plans tailored to their specific care requirements have a beneficial impact on their readiness for discharge. Additionally, the study demonstrates that enhancing psychological resilience plays a mediating role in facilitating discharge readiness. Implications for the Patient Care: Patients who feel ready for discharge are less likely to be hospitalised and their recovery may be faster. Including the patient in the discharge plan, taking individual needs into consideration and disseminating programmes to increase resilience should be an integral part of holistic care. Reporting Method: The STROBE checklist was applied in the reporting of the finding.