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The studies evaluating the impact of Her2 levels in neoadjuvant setting have conflicting data. The aim of the study was to evaluate the prognostic impact of Her2 status in early triple negative breast cancer(TNBC). In the study TNBC patients who were treated with neoadjuvant chemotherapy (NAC) and surgery were analyzed retrospectively. The primary aim of the study was to analyze the impact of Her2 status(Her2-0 and Her2-low) on pathological complete response (pCR). The secondary objectives were disease free survival (DFS) and overall survival (OS). 620 female triple negative breast cancer patients were evaluated. 427 patients (68.9%) had Her2-0 and 193(31.1%) had her2-low pathology. The pCR rates were similar between Her2-0 and Her2-low patients (33.0% vs. 27.5%, p = 0.098). Although Her2-0 group has better DFS (106 vs. 50 months, p = 0.002), in multivariate analysis it had a HR of 0.74 (p = 0.06). In addition, OS was similar (131 vs. 105 months, p = 0.13) with a HR of 0.88 (p = 0.61). In multivariate analysis; presence of LVI (HR:2.2 (95% CI 1.1–3.5) p = 0.001), Clinical stage T1/T2 (HR:0.39 (95% CI 0.2–0.6) p < 0.001) and lymph node negativity (HR:0.35 (95% CI 0.1–0.9) p = 0.03) were independent factors for OS. Although there were pathological and clinical differences, the pCR, DFS and OS were similar between Her2-0 and Her2-low TNBC patients. The importance of Her2 status of TNBC in neoadjuvant setting should be further studied.
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Makale Bilgileri
Dergi
Scientific Reports
ISSN
ISSN 2045-2322
Yıl
2024
/ 10. ay
Cilt / Sayı
14
Makale Türü
Özgün Makale
Hakemlik
Hakemli
Endeks
SCI-Expanded
Teşvik Puanı
4,50
· YÖKSİS Akademik Teşvik
Yayın Dili
Türkçe
Kapsam
Uluslararası
Toplam Yazar
1 kişi
Erişim Türü
Basılı+Elektronik
Alan
Sağlık Bilimleri Temel Alanı
Bilim Alanı
YÖKSİS Yazar Kaydı
Yazar Adı
EREN ORHAN ÖNDER
YÖKSİS ID
8218496