Background: Pneumothorax and lymphopenia are regarded as poor prognostic factors in covid-19 pneumonia. In this study, we aimed to determine whether there is a relationship between pneumothorax and lymphopenia in patients admitted to the intensive care unit due to COVID-19 pneumonia and evaluate whether lymphocyte count can be used to predict the development of pneumothorax. Methods: We retrospectively reviewed the records of 50 patients with COVID-19 pneumonia who developed pneumothorax and underwent tube thoracostomy at our hospital’s intensive care units. Results: There were 32 women and 18 men, with a mean age of 67.98 years. Of the patients who developed pneumothorax, 78% were intubated. 86% of the patients with pneumothorax died. The mortality risk in patients with pneumothorax decreased 0.198 times as lymphocyte count increased. In ROC curve analysis based on intubation status, a cut-off value 1.02 for lymphocyte count is statistically significant. Conclusions: In this study, we observed that intubated patients had a high likelihood of developing pneumothorax and that concomitant deep lymphopenia was directly associated with mortality. The results highlight that during intensive care follow-up, it must be kept in mind that poor prognostic factors can interact to result in more serious prognostic implications.