This study explores the connections among spiritual well-being, patience, and the sense of meaning in the lives of parents with children with special educational needs. Participants completed four crucial surveys: The Meaning of Life Scale, the Spiritual Well-Being Scale, and the Patience Scale. Hayes’ Process macro and bootstrap technique were employed. Patience strongly correlates with both spiritual well-being and the sense of meaning in life. The research also indicates that spiritual well-being partially mediates the relationship between patience and the sense of meaning in life for parents of children with special educational needs.