The building industry, responsible for a large proportion of energy consumption, is looking for solutions to reduce energy consumption. This study proposes biomimetic facades to ensure thermal comfort. Firstly, it examined biomimetic façade systems in the literature. Then, it analyzed the thermoregulation methods of nature, the level of biomimicry, and the strategies used by living things. As a result of the analyses, biological information regarding the three selected phenomena was expanded upon, determining how to transfer the biomimicry method to a building envelope. Energy simulations were conducted on the glass façade of the Süleyman Pasha Bath to evaluate the envelope’s energy efficiency. It was found that nature-inspired methods significantly contributed to the building’s energy consumption when examining the simulation results of the façade designed.