The aim of this study was to examine the impact of a self-compassion psychoeducation programme on the levels of self-compassion and professional quality of life among healthcare workers. The study involved the participation of 14 female and 8 male healthcare workers employed at a major state hospital in Ankara. The experimental and control groups were established through a convenience sampling method. The experimental group engaged in a 7-session “Self-Compassion Psychoeducation Program” spanning approximately 90 min per session, while the control group did not receive any form of training. The “Self-Compassion Scale” consisting of 24 items and the “Professional Quality of Life Scale” consisting of 30 items were used in the study. In this study, a quasiexperimental model with a pretest-posttest experiment and a control group was used. Descriptive statistics were used to test the research questions, and the Wilcoxon Ranked Signs Test and Mann‒Whitney U Test were used to determine the significance of the difference between pretest and posttest measurements within and between groups. Upon the conclusion of the experimental intervention, the results indicated that the mean self-compassion scores within the experimental group were significantly higher than those in the control group. While the subdimensions of compassion satisfaction and compassion fatigue within the realm of professional quality of life did not exhibit a substantial difference, the burnout subdimension demonstrated a noteworthy decrease in favor of the experimental group.