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Objective: Immune responses to SARS-CoV-2 are the main cause of tissue damage in coronavirus disease 2019. However, the pathophysiological mechanism of the disease has not been fully elucidated. The aim of this study was to examine T cell subsets of pregnant women infected with SARS-CoV-2 and evaluate the relationship between the possible differences in trimesters and clinical findings of the disease. Materials and Methods: Fifty-six pregnant patients with SARS-CoV-2 and 61 healthy pregnant controls were included in the study. T cell subsets were analyzed by flow cytometry. Results: The CD3+ total T cell (p = 0.006 and p = 0.027) of pregnant patients infected with SARS-CoV-2 in second and third trimesters was found to be lower than in the control group. CD3+CD4+ helper T cell (p = 0.035), Treg (p = 0.001), and Treg/Th17 ratio (p = 0.001) were found to be lower in the third trimester patients infected with SARS-CoV-2 than in the controls. Significant decreases were observed only in the Treg (p = 0.001) and Treg/Th17 ratio (p = 0.001) in the first trimester patients infected with SARS-CoV-2 compared to the controls. When trimesters were compared in terms of T subsets, no difference was found (p > 0.05). Conclusion: The CD3+ total T cell (p = 0.001), CD3+CD4+ helper T cell (p = 0.011), Treg (p = 0.001), and Treg/Th17 ratio (p = 0.001) were found to be lower in pregnant women infected with SARS-CoV-2. This difference was associated with the development of pneumonia but not with adverse pregnancy outcomes.
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Belge Türü
Kaynak: INTERNATIONAL IMMUNOPHARMACOLOGY
Anahtar Kelimeler (WoS)
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Scimago Dergi Bilgisi
Otomatik ISSN Eşleştirmesi
2023 yılı verileri
International Immunopharmacology
Q1
SJR Quartile
1,167
SJR Skoru
155
H-Index
Kategoriler: Pharmacology (Q1) · Immunology (Q2) · Immunology and Allergy (Q2)
Alanlar: Immunology and Microbiology · Medicine · Pharmacology, Toxicology and Pharmaceutics
Ülke: Netherlands
· Elsevier B.V.
Bu bilgiler makale yılına göre Scimago veritabanından ISSN eşleştirmesiyle otomatik getirilmektedir.
Dergi sıralama verileri Scimago'nun ilgili yılı baz alınmaktadır.
Anahtar Kelimeler
Makale Bilgileri
Dergi
Elsevier BV
ISSN
1567-5769
Yıl
2023
/ 11. ay
Cilt / Sayı
124
Makale Türü
Özgün Makale
Hakemlik
Hakemli
Endeks
SCI-Expanded
JCR Quartile
Q1
Teşvik Puanı
2,00
· YÖKSİS Akademik Teşvik
Yayın Dili
Türkçe
Kapsam
Uluslararası
Toplam Yazar
9 kişi
Erişim Türü
Basılı+Elektronik
Alan
Sağlık Bilimleri Temel Alanı
İmmünoloji ve Alerji Hastalıkları
YÖKSİS Yazar Kaydı
Yazar Adı
KULHAN MEHMET, ÖZDEMİR HÜLYA, BİLGİ AHMET, ÇELİK ÇETİN, AKTUĞ DEMİR NAZLIM, TÜRK DAĞI HATİCE, UÇAR MUSTAFA GAZİ, KULHAN NUR GÖZDE, ARTAÇ HASİBE
YÖKSİS ID
7780364