During machining, Inconel-800 superalloy is a difficult material to cut. These obstacles increase the temperature in the cutting zone, resulting in damage to both the workpiece and the cutting tool. Studies on milling Inconel-800 superalloys are limited in the literature. The processability of these superalloys under different sustainable cooling conditions is important. This research investigates the effects of minimum quantity lubrication (MQL) and cryogenic cooling techniques on Inconel-800 nickel alloys milling. The evaluations of surface roughness, tool wear, cutting temperature, chip morphology, and power consumption were carried out. It was established that the MQL environment reduces tool wear. It was discovered that the cryogenic environment is superior in terms of surface roughness, the temperature of the cutting, and the amount of power that is required. As the transition from the dry environment to the cryogenic environment, the size of the chips obtained gradually decreases. The Taguchi technique was used to find the most influential elements on the response parameters, and the study was carried out with minimal error rates.