Failure of self-control is one of the core characteristics of numerous mental health issues. The significance of self-control for mental health is well known, but studies investigating the association between self-control and mental health and the mechanisms underlying this association are quite limited, especially in adolescents. The current cross-sectional study aimed to test the mediating role of resilience in the relationship between self-control and mental health (i.e. psychological well-being and mental health problems) in adolescents. The sample comprised 405 high school students from a state school in one of the major cities of Turkey. Participants’ ages ranged from 13 to 18 years (Mage= 15.94, SD = 1.11), and 34.6% identified as male and 65.4% as female. Findings showed that self-control was positively correlated with psychological well-being and resilience but negatively correlated with mental disorders. Additionally, resilience mediated the association between self-control and mental health disorders as well as the association between self-control and psychological well-being. The study's results are discussed in the context of previous research, and implications for psychologists and mental health professionals working in schools are offered.