The authors of this study aimed to determine the effects of coping strategies and conflict resolution styles on postpartum depression in heterosexual mothers in the postpartum period in Turkey. A descriptive, cross-sectional study was conducted with 369 mothers with babies aged 1–12 months. The study was carried out between October 1, 2021, and December 1, 2021, in the pediatric outpatient clinic of the Medical Faculty Hospital of a province in the Central Anatolian Region of Turkey. Seventy-four (20.1%) mothers had scores above the depression scale cu-off point (>13). Having problems in marriage, getting a low score on the spouse’s self-perception scale of dyadic coping with stress, and having negative, nonsubmissive, and retreating conflict resolution styles were found to be important factors associated with postpartum depression (p < .05). The incidence of postpartum depression was found to be associated with having problems in the marriage, not having good dyadic coping strategies, and having negative conflict resolution styles.