Objective: Chronic age related medical problems and blood-borne viral infections may be overlooked by the clinicians in Hemophilia A, and likewise Hemophilia A patients may not be concerned sufficiently about their medical conditions other than hemophilia A. We aimed to investigate the comorbidities and the blood borne viral infections observed in the adult hemophilia A patients in our tertiary center. Methods: Adult hemophilia A patients diagnosed between the years of 1961 and 2007 were reviewed retrospectively for analysis. Demographic data, comorbidities, body mass indexes and markers for viral infections were recorded. Results: A total of 26 patients were in strict follow up in our Hemophilia A cohort. Hypertension (19%) and nephrolithiasis (19%) were the most common comorbidities. Being obese (Body Mass Index≥30 kg/m2) was not found as a risk factor for diabetes (p=1.000), hypertension (p=0.280), and hepatosteatosis (p=0.546). Two cases had positive Hepatitis B virus and 2 had positive Hepatitis C virus load. Conclusion: The results of our present study revealed that hypertension unawareness was high and incident diabetes is also a problem for Hemophilia A patients. Clinicians should be aware of blood-borne pathogens and other comorbidities; they should perform screening tests.