The continuing pandemic of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was emerged in China, and has spread rapidly all over the whole world. Thousands of cases and deaths reported each day and it is an exceptional situation in which emergency response is required for many patients. While COVID-19 cases are seen in all age groups, death rates are high in cases of cancer that cause immunodeficiency, especially in elderly people with impaired immune systems, in those with chronic diseases. The interaction between infections and the immune system is clear and there is a lot of relevant literature information. By keeping the immune system strong, infections can be overcome with less damage, and the harmful effects of inflammation and death rates can be reduced. Vitamins A, C and D are effective in the active functioning of the immune system, and their deficiencies have many adverse conditions, particularly susceptibility to infections. Although there is no specific treatment method, antiviral drug or vaccine with proven reliability for the treatment of COVID-19, the drugs recommended by the World Health Organization are being used. The effectiveness and efficiency of these drugs are controversial. In addition to these drugs, alternative treatment approaches are needed. In this literature review, the importance of vitamins A, C and D on the pathophysiology of SARS-CoV-2 and on the early-stage administration of high-dose intravenous (IV) C, oral A and D vitamins, which are alternative approaches, in the treatment of COVID-19 is shared.