Cornu cutaneum is a lesion with hyperkeratoses resembling that of an animal horn and its length varies from a few millimeters to centimeters. Cornu cutaneum is most commonly located in face, ears and other exposed areas. Cornu cutaneum may be associated with benign, pre-malignant and malignant lesions. In this case report we present a 71 years old woman suffering from two cornu cutaneum of which one is called giant cornu cutaneum located in the right cheek for 5 years.