Palmoplantar keratodermas (PPKs) are a group disease characterized by thickening of palms of the hands and soles of the feet. They may be inherited or acquired. Diffuse, focal and punctate forms are the main groups. Abnormal proliferation of stratum corneum is the main problem in PPKs. In this study, the patient who admitted to our outpatient clinic with hyperkeratotic nodular lesions in the palm of the hand and the sole of the foot was discussed.