COVID-19, which emerged in December 2019, has affected the entire world. Therefore, COVID-19 has been a subject of research in various disciplines, especially in the field of health. One of these studies was the report made by the Deep Knowledge Group (DKG) consortium in which safe regions for COVID-19 were determined. In the report, the main criteria of quarantine efficiency, government efficiency of risk management, monitoring and detection, health readiness, regional resilience, and emergency preparedness are used in the evaluation of countries and regions (alternatives). As the data and research structure used in this report are based on multi-criteria, the purpose of this study is to evaluate and analyse the safety levels of 100 regions in the world in terms of COVID-19 using Technique for Order Performance by Similarity to Ideal Solution (TOPSIS), Vise Kriterijumsa Optimizacija I Kompromisno Resenje (VIKOR) and Complex Proportional Assessment (COPRAS) methods. The data and information required in the methods were obtained from a report prepared by the DKG. The results of the methods were compared with the ranking results presented in a report of the DKG. Accordingly, it has been observed that the method that provides the closest results to the results of the report is the COPRAS method, and the method that gives the most distant results is the VIKOR method.