In the present paper, a new family of sampling type operators is introduced and studied. By the composition of the well-known generalized sampling operators of P.L. Butzer with the usual differential and anti-differential operators of order m, we obtain the so-called m-th order Kantorovich type sampling series. This family of approximation operators are very general and include, as special cases, the well-known sampling Kantorovich and the finite-differences operators. Here, we discuss about pointwise and uniform convergence of the m-th order Kantorovich type sampling series; further, quantitative estimates for the order of approximation have been established together with asymptotic formulas and Voronovskaja type theorems. In the latter results, a crucial role is played by certain algebraic moments of the involved kernels, that can be computed by resorting to the their Fourier transform and to the well-known Poisson’s summation formula. By means of the above results we become able to solve the problems of the simultaneous approximation of a function and its derivatives, both from a qualitative and a quantitative point of view, and of the linear prediction by samples from the past.