Chirality has a crucial effect on clinical, chemical and biological research since most bioactive substances possess chirality in the natural world. Thus, new effective methods and/or (nano)materials are required to explain chiral recognition of chiral substances, which always become a hot topic in pharmaceutical and chemo/biological study. Recently, the researchers have developed new methods by using (nano)materials which can offer many advantages, and they have received considerable attention in chiral recognition. In this review, we report an overview of chiral sensors in a view of various transduction principles including electrochemical, QCM and optical measurements used for detection and discrimination of chiral molecules. We discuss the general aspects and the used materials for the construction of chiral sensors with selected studies between 2009 and 2019. Additionally, we explore the capabilities of how these materials can help to fabricate simple but efficient chiral sensors. Finally, we discuss the challenges and future outlooks.