In the present paper, we introduce a new sequence of linear positive operators based on (p, q)-integers. To approximate functions over unbounded intervals, we introduce Baskakov-Durrmeyer type operators using the (p, q)-Gamma function. We investigate rate of convergence of new operators in terms of modulus of continuities and obtain their approximation behavior for the functions belonging to Lipschitz class. At the end, we present a modification of new operators preserving the test function x.