Objectives: To assess nasal cycle, nasal mucosal pH and mucociliary clearance time in patients with Parkinson's disease and healthy control subjects. Methods: Patients with idiopathic Parkinson's disease and healthy control subjects were recruited. Presence of the nasal cycle, nasal mucosa pH and mucociliary clearance time were investigated in all participants. Results: The study included 27 patients and 24 control subjects. The nasal cycle was present in significantly fewer patients than controls. Nasal pH and mucociliary clearance time were significantly higher in patients than in controls. Conclusions: Parkinson's disease is associated with alterations in nasal cycle, nasal mucosa pH and mucociliary clearance time. Measurements of these nasal parameters may be useful for the early diagnosis of autonomic and olfactory dysfunction in Parkinson's disease. © The Author(s) 2013.