In idiopathic thrombocytopenic purpura (ITP), a quite prevalent autoimmune hematological disease, thrombocytopenia is observed because of platelet destruction caused by immunological mechanisms. ITP usually leads to bleeding. Nevertheless, ITP, although rarely observed, may lead to thrombotic complications, including ischemic stroke. The present case is a female patient with ITP who developed cerebral infarction due to thrombus in the left middle cerebral artery. Our report reveals that severe ischemic stroke as well as bleeding may be encountered while monitoring an ITP case.