Premature ejaculation (PE) is the most common sexual problem experienced by men, and It affects 20%-30% of them. Pulsed radiofrequency (PRF) neuromodulation has been shown to be an effective treatment for a wide range of pain conditions. We used PRF to treat PE by desensitizing dorsal penile nerves in patients resistant to conventional treatments. Fifteen patients with a lifelong history of PE, defined as an intravaginal ejaculatory latency time (IELT) of <1 minute that occurred In more than 90% of acts of intercourse and was resistant to conventional treatments, were enrolled in this study. Patients with erectile dysfunction were excluded. The mean age of the patients was 39 ± 9 years. Before and 3 weeks after the treatment, IELT and sexual satisfaction score (SSS; for patients and their partners) were obtained. The mean IELTs before and 3 weeks after procedure were 18.5 ± 17.9 and 139.9 ± 55.1 seconds, respectively. Side effects did not occur. Mean SSSs of patients before and after treatment were 1.3 ± 0.3 and 4.6 ± 0.5, and mean SSSs of partners before and after treatment were 1.3 ± 0.4 and 4.4 ± 0.5, respectively. In all cases, IELT and SSS were significantly increased (P < .05). None of the patients or their wives reported any treatment failure during the follow-up period. The mean follow-up time was 8.3 ± 1.9 months. It is early to conclude that this new treatment modality might be used widely for the treatment of PE; however, because it is an innovative modality, placebo-controlled studies (eg, sham procedure), with larger numbers of patients and Including assessment of penile sensitivity (eg, biothesiometry), are needed. Copyright © American Society of Andrology.