Eccrine hidrocystomas (EHs) are benign cystic lesions of the eccrine ducts. They may have a chronic course and seasonal variation, and have a female predilection. Solitary EH can be easily treated by surgical excision, whereas multiple lesions are difficult to treat. We report a 65-year-old woman with sarcoidosis and multiple EHs, who was treated with cryotherapy, which resulted in a reduction in lesion number of > 90%. To our knowledge, this is the first report of cryotherapy used for EH treatment. If this case is confirmed by further studies, cryotherapy may be a viable treatment option for EH.