The present work focused on antioxidant and enzyme inhibitory potential of different solvent extracts (ethyl acetate, methanol and water) from Artedia squamata. Cholinesterase, tyrosinase, α-amylase and α-glucosidase inhibitory activities of the extracts were tested by microtitre plate assays. Antioxidant abilities were tested using free radical scavenging (DPPH and ABTS), reducing power (FRAP and CUPRAC), total antioxidant capacity and ferric ion chelating assays. The total phenolic contents of these extracts ranged from 26.24 to 35.16 mg GAEs/g extract. Methanol and water extracts showed higher phenolic content, DPPH and ABTS scavenging activity and reducing power activities, while ethyl acetate extract had highest chelating and inhibition abilities on AChE, α-amylase and α- glucosidase. With regard to tyrosinase inhibitory activity, water extract showed a good inhibitory activity with 11.91 mg KAEs/g. Present study showed that Artedia squamata can be considered as good source of natural agents for food and drug applications.