The objective of this study was to determine the energy balance and greenhouse gas (GHG) emissions associated with the production of industrial hemp (Cannabis sativa L.) under semi-arid Central Anatolian conditions. A field experiment was conducted using the registered industrial hemp cultivar ‘Vezir’ under semi-arid conditions, and energy use indicators and greenhouse gas emissions were quantified through an input–output analysis based on field-level agricultural inputs and biomass yield. The total energy input was calculated as 13,688.50 MJ ha–1, of which chemical fertilizers (54.339%) and diesel fuel (32.09%) jointly accounted for more than 90%, followed by irrigation water (4.66%), machinery 2.87%), and human labor (0.21%). The corresponding energy output reached 388,073.80 MJ ha–1, yielding an energy use efficiency of 28.35, a specific energy of 0.62 MJ kg–1, an energy productivity of 1.61 kg MJ–1 and a net energy of 374,385.28 MJ ha–1. Of the total energy input, 36.95% was direct and 63.05% indirect, while 89.35% originated from non-renewable sources and only 10.65% originated from renewable sources. Total GHG emissions amounted to 590.14 kg CO2 eq ha–1, with diesel fuel and nitrogen fertilizer identified as the dominant emission sources. These findings indicate that industrial hemp combines high productivity with low environmental burdens under semi-arid conditions. Beyond its favorable energy balance, hemp offers potential contributions to climate-smart agriculture through efficient resource use, reduced greenhouse gas emissions per unit of output, and diversification of cropping systems in water-limited environments. Therefore, industrial hemp can support the transition toward more sustainable and resilient agricultural systems in semi-arid regions of Türkiye and similar agroecological zones.