The goal of our study was to compare the clinical findings, laboratory, and imaging results of 15 individuals with uncommon mesenteric panniculitis (MP) to the literature. A case series. The General Surgery Department of Konya City Hospital, Turkey, between January 2014 and December 2021. Patients who were followed up on and treated for MP in a tertiary university hospital’s general surgery clinic. A total of 2361 patient computer tomography scans were evaluated, and archive records were used to compile data for 15 patients with MP. The patients’ demographics, complaints, hospitalization requirements, therapy methods, laboratory, and radiographic characteristics were all analyzed. Abdominal pain was the most common complaint among the patients (80%). This was followed by nausea, vomiting (40%), chest pain (33%), and diarrhea (7%). Fat halo sign was seen in 8 patients due to mesenteric vascular involvement. In 5 patients, an image consistent with mesenteric adenitis >10 mm was found. Four patients exhibited a pseudo capsule appearance, and 2 had a mesenteric mass pushing on the intestinal loops. MP is a disease that should be considered in the differential diagnosis of patients who present to the emergency department with abdominal pain, as it will ensure that the patient receives the appropriate treatment and reduce the high rate of patients discharged with the diagnosis of nonspecific abdominal pain.