Situs inversus totalis (SIT) is a rare congenital anomaly characterized by the mirror-image transposition of the normal anatomical positions of major visceral organs and vascular structures. The reversed placement of cardiovascular structures observed in SIT may lead to additional technical challenges in endovascular treatment procedures. This paper presents the transarterial radioembolization (TARE) treatment applied to a 59-year-old man with SIT diagnosed with liver metastasis from rectal cancer. A literature review revealed no publications regarding the application of TARE in patients with SIT. This case is significant in shedding light on interventional oncologic treatments in patients with similar anatomical variations.