Özet bildiri
Uluslararası
FİNLANDİYAÜlke
23.0Etkinlik Yılı
Anahtar Kelimeler
Radiotherapy is an important part of oncological treatment protocols in headand neck malignancies. Many side effects of the radiotherapy have beenreported in the literature. The aim of this study is to evaluate the efficacyof adipose-derived stem cells(ASCs) and platelet- rich plasm(PRP) in theprevention of radiotherapy induced skin side effects.Materials and MethodsHuman follicular units including epidermis dermis hair erector-pili muscleand sweat glands as a mini organ were transplanted into 2 immunodeficientnude mice. hen these follicles were transformed to the anagen phase 10 Gyradiotherapy was applied to the transplanted area. After radiotherapy micewere randomly divided into 4 groups. Saline human PRP human ASCs andASCsPRP were locally applied to the transplanted area of group 1 2 3 4 respectively. Before and after RT epithelization of the biopsy sites rootlengths and body elongation of follicular hair were evaluated macroscopically.Dystrophic changes inammation degeneration of the hair follicle andepidermal atrophy fibrosis keratinization degrees of surrounding skin wereevaluated microscopically. Cell proliferation (Ki-67) anti- apoptosis (Bcl-2) cellular differentiation-signaling (-catenin) of follicular units and surroundingskin were evaluated by immunohistochemical examinations.ResultsWhen compared to pre-RT periods the most similar epithelization time root lengths and weekly elongation of the hair follicle were obtained in thepost-RT ASCsPRP group and it was statistically significant. Increasing ofthe dystrophic changes inammation degeneration and decreasing of theproliferation anti-apoptosis cellular differentiation-signaling in the follicularunits was highest in the saline group and the lowest in the ASCsPRPgroup. Increasing of the atrophy fibrosis keratinization and decreasing ofproliferation anti- apoptosis cellular differentiation-signaling in the skin washighest in the saline group and the lowest in the ASCsPRP group.
Etkinlik Bilgileri
Etkinlik AdıEuropean Assocıatıon Of Plastıc Surgeons
ÜlkeFİNLANDİYA
ŞehirHELSİNKİ
Etkinlik Başlangıcı23 Mayıs 2019
Etkinlik Bitişi25 Mayıs 2019
Bildiri Bilgileri
Bildiri TürüÖzet bildiri
Sunum TürüSözlü Sunum
KapsamUluslararası
Yayın DurumuYayımlanmış
Yayın Diliİngilizce
YazarlarEVİN NUH,AKDAĞ OSMAN,AKTAN TAHSİN MURAD,DUMAN SELÇUK,HARMANKAYA İSMAİL,YAVAŞ GÜLER,TOSUN ZEKERİYA
Yazar Sayısı7
Basım TürüElektronik
Alan Bilgisi
Sağlık Bilimleri Temel Alanı->Tıbbi Patoloji