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Phenolic constituent, antioxidative and tyrosinase inhibitory activity of Ornithogalum narbonense L. from Turkey: A phytochemical study
Scopus
Toplam 116 atıf DOI
This study examined the antioxidant and anti-tyrosinase activity and phenolic profiles of three extracts (ethyl acetate, methanol and water) obtained from different anatomical parts (bulb, stem and seed) of Ornithogalum narbonense. Antioxidant activity of the extracts was evaluated using DPPH*, ABTS+*, FRAP, CUPRAC, metal chelating and phosphomolybdenum assays. Tyrosinase inhibitory activity was measured using the modified dopachrome method with l-DOPA as the substrate. Phenolic content of the extracts varied according to plant part and extraction solvent and included HPLC-DAD, epicatechin, rutin, ferulic, protocateuchic p-hydroxybenzoic, chlorogenic, caffeic, benzoic and rosmarinic acids. The ethyl acetate extract of O. narbonense bulb samples demonstrated the most antioxidant and anti-tyrosinase activity and had the highest phenolic content. All other extracts showed moderate antioxidant and anti-tyrosinase activity. O. narbonense extracts, especially ethanol extract of O. narbonense bulbs, may have dietary and medicinal applications.
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Antioxidant and enzyme inhibitory activities of disodium rabdosiin isolated from Alkanna sfikasiana Tan, Vold and Strid
Scopus
Havuzumuzda Open Access 21 atıf almış
Alkanna sfikasiana Tan, Vold and Strid is an endemic Greek species of Boraginaceae family. From the roots, the new natural product disodium rabdosiin (1) along with rosmarinic acid (2) were isolated from the methanolic extract and lanosta-7,24-dien-3β-ol (3) and linoleic acid (4) from the cyclohexane extract. From the methanolic extract of the aerial parts two flavonoids quercetin 3-Ο-β-D-glucoside (5) and quercetin 3-Ο-β-D-rutinoside (6) were isolated. The antioxidant properties exhibited good radical scavenging activity (96.00 mgTE/g for DPPH; 441.97 mgTE/g for ABTS) and reducing power ability (720.81 mgTE/g for CUPRAC and 413.94 mgTE/g for FRAP) for the new compound 1. Enzyme inhibitory activity has been also evaluated, showing inhibitory effects on AChE (4.32 mgGALAE/g), BChE (3.63 mgGALAE/g) and α-amylase (3.83 mmolACAE/g). Consequently, our study could provide a potential candidate for developing novel phyto-pharmaceutics and it could be considered a new starting point on the studied species.
Atıf Yapan Makale Bilgileri
Kurumlar (2)
National & Kapodistrian University of Athens, School of Health Sciences
Athens, Greece
Selçuk Üniversitesi
Selçuklu, Turkey