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Phenolic constituent, antioxidative and tyrosinase inhibitory activity of Ornithogalum narbonense L. from Turkey: A phytochemical study
Scopus
Toplam 116 atıf DOI
This study examined the antioxidant and anti-tyrosinase activity and phenolic profiles of three extracts (ethyl acetate, methanol and water) obtained from different anatomical parts (bulb, stem and seed) of Ornithogalum narbonense. Antioxidant activity of the extracts was evaluated using DPPH*, ABTS+*, FRAP, CUPRAC, metal chelating and phosphomolybdenum assays. Tyrosinase inhibitory activity was measured using the modified dopachrome method with l-DOPA as the substrate. Phenolic content of the extracts varied according to plant part and extraction solvent and included HPLC-DAD, epicatechin, rutin, ferulic, protocateuchic p-hydroxybenzoic, chlorogenic, caffeic, benzoic and rosmarinic acids. The ethyl acetate extract of O. narbonense bulb samples demonstrated the most antioxidant and anti-tyrosinase activity and had the highest phenolic content. All other extracts showed moderate antioxidant and anti-tyrosinase activity. O. narbonense extracts, especially ethanol extract of O. narbonense bulbs, may have dietary and medicinal applications.
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Phytochemical and biological activities of Silene viridiflora extractives. Development and validation of a HPTLC method for quantification of 20-hydroxyecdysone
Scopus
Havuzumuzda 28 atıf almış
Silene viridiflora (Caryophyllaceae) has adaptogen, tonic, actoprotector and immunomodulator properties that are mainly attributed to ecdysteroids. The aim of the present study is to investigate the chemical constituents of essential oil as well as the 20-hydroxyecdysone content in the methanol extract S. viridiflora and its related biological activity. GC–MS analysis showed the essential oil of S. viridiflora to have a complex composition, which was dominated by methyl palmitate (8.05%), 3-hexen-1-ol (7.54%), 3-hexenyl benzoate (3.86%), β-myrcene (3.80%), 1,1-diethoxy-2-phenylethane (3.65%), hexahydrofarnesyl acetone (3.20%) and 4-terpineol (2.47%). A high performance thin-layer chromatography (HPTLC) method was developed to analyze the methanolic extracts of S. viridiflora and to quantify the main ecdysteroid, 20-hydroxyecdysone. Validation showed that the method was accurate over the entire calibration range and resulted in errors of less than 10% in the 100–815 μg/ml concentration range. Antioxidant and enzyme inhibitory potentials of methanol extract and individual compounds of S. viridiflora were evaluated. The results could provide a starting point for designing novel phyto-pharmaceuticals.
Atıf Yapan Makale Bilgileri
Kurumlar (3)
BOKU University
Vienna, Austria
Selçuk Üniversitesi
Selçuklu, Turkey
S. Yu. Yunusov Institute of the Chemistry of Plant Substances Uzbekistan Academy of Sciences
Tashkent, Uzbekistan