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Phenolic constituent, antioxidative and tyrosinase inhibitory activity of Ornithogalum narbonense L. from Turkey: A phytochemical study
Scopus
Toplam 116 atıf DOI
This study examined the antioxidant and anti-tyrosinase activity and phenolic profiles of three extracts (ethyl acetate, methanol and water) obtained from different anatomical parts (bulb, stem and seed) of Ornithogalum narbonense. Antioxidant activity of the extracts was evaluated using DPPH*, ABTS+*, FRAP, CUPRAC, metal chelating and phosphomolybdenum assays. Tyrosinase inhibitory activity was measured using the modified dopachrome method with l-DOPA as the substrate. Phenolic content of the extracts varied according to plant part and extraction solvent and included HPLC-DAD, epicatechin, rutin, ferulic, protocateuchic p-hydroxybenzoic, chlorogenic, caffeic, benzoic and rosmarinic acids. The ethyl acetate extract of O. narbonense bulb samples demonstrated the most antioxidant and anti-tyrosinase activity and had the highest phenolic content. All other extracts showed moderate antioxidant and anti-tyrosinase activity. O. narbonense extracts, especially ethanol extract of O. narbonense bulbs, may have dietary and medicinal applications.
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Chemical variability, pharmacological potential, multivariate and molecular docking analyses of essential oils obtained from four medicinal plants
Scopus
Havuzumuzda 29 atıf almış
Essential oils (EOs) hold tremendous medicinal attributes and are greatly exploited industrially worldwide. In the present study, the chemical composition of five EOs prepared from four aromatic plants were revealed together with their inhibitory activities against five key clinical enzymes (α-amylase, α-glucosidase, tyrosinase, acetyl- and butyryl-cholinesterase). Limonene (84.3%) and sabinene (38.1%) were the most dominant constituents present in Citrus aurantium fruit peel and leaf EOs respectively. Turmerone (31.4%), ar-turmerone (16.1%), and turmerol (14.6%) were the principal components identified in Curcuma longa rhizome EO. Additionally, Morinda citrifolia fruit EO was abundant in octanoic acid (78.9%), while carvacrol (17.9%), δ-3-carene (15.2%), and camphor (12.9%) were predominant in Plectranthus amboinicus EO. The investigated EOs were all active inhibitors of acetylcholinesterase, amylase, and tyrosinase. Morinda citrifolia and P. amboinicus EOs inhibited butyrylcholinesterase exclusively, while M. citrifolia and C. aurantium fruit peel EOs displayed inhibition against glucosidase as well. Due to strong interactions with their active sites, molecular docking showed turmerone followed by carvacrol to have the highest binding affinities with target enzymes. Moderate to strong antioxidant potential was also demonstrated by all EOs. However, P. amboinicus EO presented the most potent antioxidant capacity and contained the highest amount of phenolics, while M. citrifolia EO was the weakest among all. Besides, a strong positive correlation was noted between EOs’ antioxidant capacities and total phenolic content. With the exception of C. aurantium leaf and C. longa EOs which showed similar bioactivities and were grouped together, the other EOs were subdivided into distinct groups by principal component analysis. Altogether, this study highlighted interesting pharmacological properties of the investigated EOs that could serve as sources of bioactive ingredients with potential industrial applications.
Atıf Yapan Makale Bilgileri
Kurumlar (4)
Duy Tan University
Da Nang, Viet Nam
Salahaddin University-Erbil
Erbil, Iraq
Selçuk Üniversitesi
Selçuklu, Turkey
University of Mauritius
Reduit, Mauritius