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Chemical composition, antioxidant and enzyme inhibitory properties of different extracts obtained from spent coffee ground and coffee silverskin
Scopus
Open Access Toplam 119 atıf DOI
In a world where an eco-friendlier approach is becoming more and more necessary, it is essential to reduce waste production and to reuse residues of the company’s supply chain. Coffee silverskin (CS) and spent coffee ground (SCG), two by-products of coffee production, are important sources of bioactive compounds and, for this, some authors have proposed their reuse in the nutraceutical, food, and cosmetic sector. However, their potential enzyme inhibitory properties have been poorly investigated. Hence, the objective of the current work was to study the enzymatic inhibitory activities against acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, and tyrosinase of different extracts of CS and SCG. Before these in vitro bioassays, the phytochemical composition of each extract was investigated via colorimetric assays and HPLC-MS/MS analysis. In addition, the antioxidant activities were evaluated by different chemical approaches. SCG extracts contained a higher content of bioactive compounds, notably the SCG EtOH:H2O extract was the richest in caffeine and possessed the highest antioxidant activities. The hydroalcoholic and methanolic extracts were shown to be the most active against all tested enzymes, while the water extracts displayed lower activity. Our results showed a weak correlation between bioactive compounds and enzyme inhibitory effects, proving inhibitory activities likely due to non-phenolic molecules such as alkaloids and terpenoids. Obtained findings could be a starting point to develop novel nutraceuticals from CS and SCG.
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Evaluation of the chemical constituents, antioxidant and enzyme inhibitory activities of six Yemeni green coffee beans varieties
Scopus
Havuzumuzda 23 atıf almış
Coffee arabica L. is an economical crop cultivated in many countries including Yemen. The present study evaluated the phytochemical contents of the methanolic extracts, prepared by maceration, of six Yemeni green coffee beans varieties namely Esmaeli, Hamadi, Harazi, Mattari, Odaini and Yafei. Antioxidant (phosphomolybdenum, antiradical, reducing power and ferrous chelating), and enzyme inhibition activity of the extracts against acetylcholinesterase butyrylcholinesterase, tyrosinase, α-glucosidase, and α-amylase were also studied. Quantification of total phenols revealed that all green beans varieties were richer in their total polyphenolic (63.77–110.98 mg gallic acid equivalent per g of extract) content than their flavonoids one (2.86–5.57 mg rutin equivalent per g of extract). HPLC-MS/MS analysis of 30 selected bioactive compounds showed that all varieties had the same types of phytoconstituents with differences in their relative abundance. Caffeine (1613.89–2466.38 μg/g) followed by 5-caffeoylquinic acid (1017.63–1313.39 μg/g) were the dominant compounds in all varieties with caffeine more abundant in Esmaeli variety while 5-caffeoylquinic acid in Odaini variety. All varieties displayed a pronounced antioxidant property in all the in vitro assays with Odaini variety significantly (p < 0.05) exerted the highest anti-DPPH radicals (253.96 mg Trolox equivalent (TE)/g), metal chelating (19.73 mg Disodium edetate equivalents/g), Cu2+ (441.11 mg TE/g) and Fe3+ (221.04 mg TE/g) reducing activities. Furthermore, the majority of green coffee beans varieties showed comparable enzyme inhibition property with highest activity recorded against tyrosinase (39.35–46.96 mg kojic acid equivalents/g) and acetylcholinesterase (1.80–2.17 mg galanthamine equivalents/g) enzymes. In conclusion, all Yemeni green coffee beans varieties have proven to be rich source of biochemicals with beneficial impact on human health and could be of significant applications in food, pharmaceutical and cosmetics industry.
Atıf Yapan Makale Bilgileri
Kurumlar (5)
College of Sciences
Riyadh, Saudi Arabia
Hajji University
Hajjah, Yemen
Khartoum University
Khartoum, Sudan
Selçuk Üniversitesi
Selçuklu, Turkey
Università degli Studi di Camerino
Camerino, Italy