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Direct electron transfer from glucose oxidase immobilized on polyphenanthroline-modified glassy carbon electrode
Scopus
Toplam 120 atıf DOI
This study reports direct electron transfer (DET) from immobilized glucose oxidase (GOx) via grafted and electropolymerized 1,10-phenanthroline monohydrate (PMH). The layer of poly-1,10-phenanthroline (PPMH) was gained via electrochemical deposition, which was used to create the PPMH-modified GC-electrode (PPMH/GC-electrode). Further, the GOx was immobilized on the PPMH/GC-electrode. The effect of surface-modification by the PPMH on the electron-transfer between enzyme and electrode-surface and some other electrochemical/analytical-parameters of newly designed enzymatic-electrode were evaluated. The PPMH/GC-electrode showed superior DET to/from flavine adenine dinucleotide cofactor of GOx, while some redox-compounds including ferrocene and K3[Fe(CN)6] were completely electrochemically inactive on the PPMH/GC-electrode. It was also found that the resulting GOx/PPMH/GC-electrode functioned as a " direct response type" glucose-biosensor. The biosensor showed excellent selectivity towards glucose and demonstrated good operational-stability. According to our best knowledge, this study is the first scientific report on electrochemical-polymerization of PMH on the GC-electrode in non-aqueous media followed by its application in the design of glucose-biosensor. © 2010 Elsevier B.V.
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Electrochemical formation of ‘synthetic receptors’ based on conducting polymers
Scopus
Havuzumuzda 4 atıf almış
Analysis of pharmaceuticals and biologically active materials recently can be performed by biosensors, which can be based on conducting polymers. Therefore, in this Mini Review some achievements in the synthesis and application of conducting polymer—polypyrrole (Ppy), which is often used in the design of sensors and biosensors, are overviewed. Some perspective methods of conducting polymer synthesis are outlined. Significant attention has been paid to electrochemical, chemical and biochemical synthesis of conducting polymers (CPs), which were developed by authors. The applicability of polypyrrole based functional layers in the design of electrochemical biosensors is overviewed. The adaptability of enzyme— glucose oxidase (GOx), which can be applied as (i) biological recognition element— in the design of glucose biosensors, (ii) a biocatalyst—in the synthesis of some above mentioned conducting polymers, is discussed. Part of biocompatibility related aspects of some conducting polymers are also discussed and some insights in the application of polypyrrole-based coatings for implantable sensors are outlined.
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Kurumlar (5)
Dr. Babasaheb Ambedkar Marathwada University
Aurangabad, India
Fizinių ir Technologijos Mokslų Centras
Vilnius, Lithuania
Odesa I.I. Mechnikov National University
Odesa, Ukraine
Selçuk Üniversitesi
Selçuklu, Turkey
Vilniaus Universitetas
Vilnius, Lithuania