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An electrochemical biosensor based on human serum albumin/graphene oxide/3-aminopropyltriethoxysilane modified ITO electrode for the enantioselective discrimination of d- and l-tryptophan
Scopus
Toplam 120 atıf DOI
A new electrochemical biosensor based on the human serum albumin/graphene oxide/3-aminopropyltriethoxysilane modified indium tin oxide electrode (ITO/APTES/GO/HSA) has been developed for the discrimination of tryptophan (Trp) enantiomers. The electrode has been characterized by scanning electron microscopy (SEM) and electrochemical techniques. The electrochemical behaviors of the enantiomeric pairs (d- and l-Trp) at the ITO/APTES/GO/HSA electrode have been investigated by cyclic voltammetry in the concentration range of 0.10-1.0. mM. A clear separation between the oxidation peak potentials of d- and l-Trp, at 0.86 and 1.26. V, respectively, has suggested that the ITO/APTES/GO/HSA electrode can be used as an electrochemical biosensor for the discrimination of Trp enantiomers. In order to find the percentage of an enantiomeric form of tryptophan in a mixture, the ITO/APTES/GO/HSA electrode is used for the simultaneous detection of d- and l-Trp which showed that the percentage of one enantiomeric form can be easily measured in the presence of the other. © 2012 Elsevier B.V.
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Chiral sensors
Scopus
Havuzumuzda 127 atıf almış
Chirality has a crucial effect on clinical, chemical and biological research since most bioactive substances possess chirality in the natural world. Thus, new effective methods and/or (nano)materials are required to explain chiral recognition of chiral substances, which always become a hot topic in pharmaceutical and chemo/biological study. Recently, the researchers have developed new methods by using (nano)materials which can offer many advantages, and they have received considerable attention in chiral recognition. In this review, we report an overview of chiral sensors in a view of various transduction principles including electrochemical, QCM and optical measurements used for detection and discrimination of chiral molecules. We discuss the general aspects and the used materials for the construction of chiral sensors with selected studies between 2009 and 2019. Additionally, we explore the capabilities of how these materials can help to fabricate simple but efficient chiral sensors. Finally, we discuss the challenges and future outlooks.
Atıf Yapan Makale Bilgileri
Kurumlar (2)
Necmettin Erbakan Üniversitesi
Meram, Turkey
Selçuk Üniversitesi
Selçuklu, Turkey