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Survey of phytochemical composition and biological effects of three extracts from a wild plant (Cotoneaster nummularia Fisch. et Mey.): A potential source for functional food ingredients and drug formulations
Scopus
Open Access Toplam 120 atıf DOI
This study was focused on the analysis of the phenolic content, antioxidant, antibacterial, anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase activity of three solvent extracts from Cotoneaster nummularia. Moreover, water extract was tested in terms of mutagenic/anti-mutagenic effects. The antioxidant activities of these extracts were evaluated by DPPH, ABTS, O2, metal chelating, phosphomolybdenum, b-carotene/linoleic acid, ferric and cupric reducing power assays. Enzyme inhibitory activities were also examined with colorimetric methods. Generally, methanol and water extracts exhibited excellent biological activities. These extracts were rich in phenolic and flavonoid content. Furthermore, Cotoneaster extracts indicated appreciable antibacterial properties against human pathogen strains. HPLC analysis showed that ferulic acid, chlorogenic acid, (-)-epicatechin and (+)-catechin were the major phenolics in extracts tested. These data offer that these extracts from C. nummularia may be considered as a potential source of biological agents for developing functional foods or drug formulations. Copyright:
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GC/MS analysis, in vitro antioxidant and enzyme inhibitory activities of the n-hexane extract of Gmelina philippensis CHAM and in silico molecular docking of its major bioactive compounds
Scopus
Havuzumuzda 5 atıf almış
Gmelina philippensis is a decorative plant distributed in South Asia and the Mediterranean region. The n-hexane extract from G. philippensis leaves has been investigated for its chemical composition, antioxidant activity, and enzyme inhibition against six enzymes – acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, and glucosidase. The main components were fatty acids, esters, and hydrocarbons, with glycidyl palmitoleate (22.11%) and 2-methyl hexacosane (10.75%) dominating in the GC/MS analysis. The extract exhibited higher Cu + + and Fe + + + reducing capacity and chelating with values of 60.18 ± 0.58 mg TE/g, 31.48 ± 0.72 mg TE/g, and 31.11 ± 0.52 mg EDTAE/g. It also displays anti-DPPH (13.46 mg TE/g) and anti-ABTS (23.50 mg TE/g) activities. Enzyme inhibition tests showed that the n-hexane extract has the best anti-tyrosinase activity (39.97 mg KAE/g) and recorded high anti-BChE activity (3.54 mg GALAE/g). The α-amylase and α-glucosidase inhibitory activity of the n-hexane extract recorded values of 0.57 and 1.62 mmol ACAE/g. In addition, the in-silico study demonstrated that the major compounds had satisfactory binding scores when docked with the enzymes under study. Hence, the n-hexane extract of G. philippensis shows great potential as a candidate for the advancement of new therapeutic approaches for oxidative stress, neurodegeneration, and diabetes mellitus.
Atıf Yapan Makale Bilgileri
Kurumlar (5)
Ain Shams University
Cairo, Egypt
Faculty of Pharmacy, Ain Shams University
Cairo, Egypt
Field of Pharmacy
Ras Sedr, Egypt
School of Pharmacy
Badr, Egypt
Selçuk Üniversitesi
Selçuklu, Turkey