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Oxidative stress in patients with primary insomnia
Progress in Neuro Psychopharmacology and Biological Psychiatry Cilt 37 ss. 247-251
Scopus Toplam 129 atıf DOI
Objective: Many physiological and pathological processes, such as infections, environmental toxins, and ionizing radiation increase bodily concentrations of oxidizing substances, known as free radicals, which lead to neurodegenerative disorders. Sleep is one of the most important factors contributing to health; however, insomnia is among the most prevalent health complaints. Methods: In this study, for the first time in the literature, we investigated the effects of primary insomnia on certain oxidative stress biomarkers. For this purpose, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and myeloperoxidase (MPO) activities and levels of reduced glutathione (GSH) and malondialdehyde (MDA) were measured in 30 patients with primary insomnia and 30 healthy volunteers. Results: Our results show that the patients with primary insomnia had significantly lower GSH-Px activity and higher MDA levels compared with the controls. Conclusion: These results may indicate the important role of sleep in attenuating oxidative stress. © 2012 Elsevier Inc.
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Atıf Yapan Yayın
Benefits of submucous resection on sleep quality, daytime and dream anxiety in patients with nasal septal deviation
Sleep and Biological Rhythms Cilt 11 ss. 227-236
Scopus Havuzumuzda 6 atıf almış
The aim of this report was to assess the frequency of poor sleep quality, daytime and dream anxiety and their response to subsequent surgical treatment for a representative group of 68 patients with nasal septum deviation. Nasal airflows and airway resistances were measured using rhinomanometry and the participants were also asked to fill in Pittsburgh Sleep Quality Index, Beck Anxiety Inventory, and Van Dream Anxiety Scale directly before the submucous resection without turbinectomy and 2 months later. Repeated measure analyses of variance models showed that patients reported significantly lower scores of poor sleep quality, daytime anxiety, and as well as dream anxiety after surgical treatment (P < 0.01). Nasal septal surgery might have beneficial effects on sleep variables in patients with deviation. © 2013 Japanese Society of Sleep Research.
Atıf Yapan Makale Bilgileri
Kurumlar (4)
Ataturk University, Faculty of Medicine Erzurum, Turkey
Erzurum Regional Training and Research Hospital Erzurum, Turkey
Selçuk Üniversitesi Selçuklu, Turkey
Van Yüzüncü Yıl Üniversitesi Van, Turkey